Novel Anti-Inflammatory and Wound Healing Controlled Released LDH-Curcumin Nanocomposite Via Intramuscular Implantation, In-Vivo Study

One of the most common problems in wounds is delayed healing and complications such as infection. Therefore, need for novel materials accelerates especially abdominal after surgery besides high efficiency safety mandatory. The rate wound healing, anti-inflammatory biocompatibility Zn-Al LDH alone loaded with Curcumin was screened via in-vivo assays through intramuscular implantation rat wall intact peritoneum cavity. implanted drugs were formed into drug release 56.78 ±1.51% within 24 h. synthesized nanocomposite characterized by thermal analysis, X-ray diffraction, Field emission scanning microscopy, resolution transmission electron microscope BET surface area. integrity blood circulation, inflammatory signs, rate, capacity tissue integration, antigenicity composite biocompatibility, auto fluorescence ability collagen bundles tensile strength muscle assessed histopathologically 7 30 days post-implantation. Excellent achieved shortest length between gap edges higher muscle. Besides emit florescence very well followed good muscles while low scar formation Curcumin-Zn/Al-LDH both acute chronic wound. No signs inflammation & LDH. vessels obstruction or bleeding observed Zn/Al-LDH more than nanocurcumin control which examined candling. Good infiltrated immune cells same groups histopathological examination. This work supports anti-inflammatory, living matter, increasing their biomedical applications this era efficacy prolonged release.